Concern about transmission of HIV infection to a person on PrEP

It is well established that preexposure prophylaxis with Truvada is effective to prevent HIV infection when the individual is 100% adherent to medication.

However, there is not much information about potential failure  and contracting this infection in spite of high adherence in a case of viral resistance.

A case from Toronto was recently reported, when a 43 y/o man contracted HIV infection in spite of beeing highly adherent to PrEP for two years.

The HIV virus he contracted was resistant to Truvada (Emtriva and Tenofovir).

This illustrates that preexposure prophylaxis is not perfect, and may not be 100% effective, therefore condom use should be part of prevention of sexual transmission of HIV infection.

HIV Infection, Why There Is Still No Cure?

It is estimated that there are about 35 million people infected with the HIV virus living in the world. Although we have come a long way in managing HIV infection, halting disease progression and making possible for infected individuals to have a normal life, there is still no cure.

 

One of the possible explanations  is the virus remains dormant in the memory CD4 + T-cells. The most probable hypothesis why there is still no cure for HIV is the assumption that the viral genetic material integrates with the host lymphocytes, mainly CD4 +T -cells and remains dormant there. These chronically “contaminated” cells serve as the viral reservoir in the HIV infected individuals.

Currently available antiretroviral medications work on various stages of viral replication, but do not affect”dormant”, proviral genetic material(DNA). More research is needed to develop effective blocking mechanisms to not allow the virus to enter the T-cells in the first place and to develop purging techniques to clean already contaminated memory cells. Hopefully this will lead to an HIV cure.

As of now the the treatment goal is to control viral replication with antiretroviral medications in order to halt the infection from progresing and to prevent HIV transmission to uninfected individuals.

 

What is Zika? How to protect yourself.

Zika is a virus, a member of the Flaviviride family that is transmitted by mosquitos.

Sexual transmission from travelers to their partners has been reported and this includes transmission through vaginal, anal and oral sex.

Transmission of this virus also was reported through contaminated blood products such as platelet transfusion.

The Zika virus outbreak in Latin America and Caribbean region appears to be growing. In the USA cases have been reported in Florida.

For travelers it is important to know about Zika endemic areas and to take proper precautions to avoid catching this virus.

Current preventive measures include:

  • Avoid traveling to the areas with active Zika, especially if pregnant or plans to become pregnant soon.
  • If travel is necessary, use air-conditioning and window screens, wear long-sleeve shirts and long pans, use permethrin-treated clothing and insect repellent.

Hepatitis C

Did you know that the estimated number of Chronic Hepatitis C cases in the United State is between 2.7 and 3.9 million.

This viral infection may not produce symptoms, but still silently damage the liver.

Get yourself tested!

Current treatment strategies of Chronic Hepatitis C are very effective and much simpler than a few years ago.

Is the Flu Shot Necessary?

The Flu season is coming soon.

Get the Flu vaccine ; it is safe, inexpensive, and provides protection for you, your family and others around you.

A little chill, body aches and a low grade fever is expected and indicates your body is having a proper response to the vaccine.

be prepare and get the Flu vaccine today